Assessment of oxidative stress-induced DNA damage by immunoflourescent analysis of 8-oxodG
SF Lee, S Pervaiz - Methods in cell biology, 2011 - Elsevier
Oxidative stress refers to the imbalance between the generation of reactive oxygen species
(ROS) and their scavenging by the inherent antioxidant defenses of the cell. The abnormal
accumulation of ROS is the underlying pathology in a variety of human diseases such as
neurodegenerative phenomena, inflammatory diseases, metabolic disorders, and cancer.
The mechanism by which abnormal accumulation of ROS contributes to pathological
conditions involves damage or oxidative modification of biomolecules, such as nucleotides …
(ROS) and their scavenging by the inherent antioxidant defenses of the cell. The abnormal
accumulation of ROS is the underlying pathology in a variety of human diseases such as
neurodegenerative phenomena, inflammatory diseases, metabolic disorders, and cancer.
The mechanism by which abnormal accumulation of ROS contributes to pathological
conditions involves damage or oxidative modification of biomolecules, such as nucleotides …
