The chaperone protein 14-3-3 interacts with 3BP2/SH3BP2 and regulates its adapter function
I Foucault, YC Liu, A Bernard, M Deckert - Journal of Biological Chemistry, 2003 - ASBMB
Lymphocyte stimulation by immunoreceptors is achieved through the activation of multiple
signaling pathways leading to cytokine gene transcription. Adapter proteins are critical
signaling components that can integrate multiple pathways by allowing the assembly of
multimolecular signaling complexes. We previously showed that the cytoplasmic adapter
3BP2 (also known as SH3BP2) promotes NFAT/AP-1 transcriptional activities in T cells
through the activation of Ras-and calcineurin-dependent pathways. However, the molecular …
signaling pathways leading to cytokine gene transcription. Adapter proteins are critical
signaling components that can integrate multiple pathways by allowing the assembly of
multimolecular signaling complexes. We previously showed that the cytoplasmic adapter
3BP2 (also known as SH3BP2) promotes NFAT/AP-1 transcriptional activities in T cells
through the activation of Ras-and calcineurin-dependent pathways. However, the molecular …
