Blocking CCL8-CCR8–Mediated Early Allograft Inflammation Improves Kidney Transplant Function
A Dangi, I Husain, CZ Jordan, S Yu… - Journal of the …, 2022 - journals.lww.com
Background In kidney transplantation, early allograft inflammation impairs long-term allograft
function. However, precise mediators of early kidney allograft inflammation are unclear,
making it challenging to design therapeutic interventions. Methods We used an allogeneic
murine kidney transplant model in which CD45. 2 BALB/c kidneys were transplanted to
CD45. 1 C57BL/6 recipients. Results Donor kidney resident macrophages within the
allograft expanded rapidly in the first 3 days. During this period, they were also induced to …
function. However, precise mediators of early kidney allograft inflammation are unclear,
making it challenging to design therapeutic interventions. Methods We used an allogeneic
murine kidney transplant model in which CD45. 2 BALB/c kidneys were transplanted to
CD45. 1 C57BL/6 recipients. Results Donor kidney resident macrophages within the
allograft expanded rapidly in the first 3 days. During this period, they were also induced to …
