Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia
BACKGROUND: Deoxyribonucleic acid microarray analyses of dorsolateral prefrontal cortex
(DLPFC) area 9 from 10 matched pairs of schizophrenic and control subjects revealed a
consistent and significant decrease (p=. 001; mean log2 signal difference=−. 58) in transcript
expression for a gene clone KIAA0417. This database entry has been recently annotated as
two highly homologous members of a heat-shock protein family (HSPA12A and HSPA12B).
METHODS: We followed up our initial results by in situ hybridization in subjects with …
(DLPFC) area 9 from 10 matched pairs of schizophrenic and control subjects revealed a
consistent and significant decrease (p=. 001; mean log2 signal difference=−. 58) in transcript
expression for a gene clone KIAA0417. This database entry has been recently annotated as
two highly homologous members of a heat-shock protein family (HSPA12A and HSPA12B).
METHODS: We followed up our initial results by in situ hybridization in subjects with …
